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Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effectsMany people using this medication do not have serious side effects.
Antibiotic medicines can cause diarrheawhich may be a sign of a new infectionIf you have diarrhea that is watery or bloodycall your doctor before using anti-diarrhea medicine.
Avoid coadministration with serotonergic psychiatric drugsegSSRIsSNRIsTCAsMAOIsunless indicated for life-threatening or urgent infectionsegvancomycin-resistant enterococcal infectionsnosocomial pneumoniacomplicated skin and skin structure infections such as methicillin-resistant S aureusdue to increased risk of serotonin syndromelinezolid may increase serotonin CNS levels by MAO-A inhibition If linezolid must be administered to a patient currently taking a serotonergic drugstop serotonergic drug immediately and monitor for CNS toxicityserotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring5 weeks if fluoxetine was takenwhichever comes firstserotonergic psychiatric medications should be stopped at least 2 weeks in advance of linezolid therapyfluoxetine should be stopped at least 5 weeks in advance due to longer half-life.
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a small degree of nonlinearity in clearance was observed with increasing doses of linezolid, which appears to be due to lower renal and nonrenal clearance of zyvox at higher concentrations.