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    Avoid coadministration with serotonergic psychiatric drugsegSSRIsSNRIsTCAsMAOIsunless indicated for life-threatening or urgent infectionsegvancomycin-resistant enterococcal infectionsnosocomial pneumoniacomplicated skin and skin structure infections such as methicillin-resistant S aureusdue to increased risk of serotonin syndromelinezolid may increase serotonin CNS levels by MAO-A inhibition If linezolid must be administered to a patient currently taking a serotonergic drugstop serotonergic drug immediately and monitor for CNS toxicityserotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring5 weeks if fluoxetine was takenwhichever comes firstserotonergic psychiatric medications should be stopped at least 2 weeks in advance of linezolid therapyfluoxetine should be stopped at least 5 weeks in advance due to longer half-life.

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    a small degree of nonlinearity in clearance was observed with increasing doses of linezolid, which appears to be due to lower renal and nonrenal clearance of zyvox at higher concentrations.

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